Lexical and Prosodic Pitch Modifications in Cantonese Infant-directed Speech

Published online 03 February 2021The functions of acoustic-phonetic modifications in infant-directed speech (IDS) remain a question: do they specifically serve to facilitate language learning via enhanced phonemic contrasts (the hyperarticulation hypothesis) or primarily to improve communication via prosodic exaggeration (the prosodic hypothesis)? The study of lexical tones provides a unique opportunity to shed light on this, as lexical tones are phonemically contrastive, yet their primary cue, pitch, is also a prosodic cue. This study investigated Cantonese IDS and found increased intra-talker variation of lexical tones, which more likely posed a challenge to rather than facilitated phonetic learning. Although tonal space was expanded which could facilitate phonetic learning, its expansion was a function of overall intonational modifications. Similar findings were observed in speech to pets who should not benefit from larger phonemic distinction. We conclude that lexicaltone adjustments in IDS mainly serve to broadly enhance communication rather than specifically increase phonemic contrast for learners.This work was supported by the University Grants Committee (HKSAR) (RGC34000118), the Innovation and Technology Fund (HKSAR) (ITS/067/18), Dr. Stanley Ho Medical Development Foundation, and the Global Parent Child Resource Centre Limited. The second author’s work is supported by the Basque Government through the BERC 2018-2021 program and by the Spanish Ministry of Science and Innovation through the Ramon y Cajal Research Fellowship, PID2019-105528GA-I00

Challenges of EGFR-TKIs in NSCLC and the potential role of herbs and active compounds: From mechanism to clinical practice

Epidermal growth factor receptor (EGFR) mutations are the most common oncogenic driver in non-small cell lung cancer (NSCLC). Epidermal growth factor receptor-tyrosine kinase inhibitors (EGFR-TKIs) are widely used in the treatment of lung cancer, especially in the first-line treatment of advanced NSCLC, and EGFR-TKIs monotherapy has achieved better efficacy and tolerability compared with standard chemotherapy. However, acquired resistance to EGFR-TKIs and associated adverse events pose a significant obstacle to targeted lung cancer therapy. Therefore, there is an urgent need to seek effective interventions to overcome these limitations. Natural medicines have shown potential therapeutic advantages in reversing acquired resistance to EGFR-TKIs and reducing adverse events, bringing new options and directions for EGFR-TKIs combination therapy. In this paper, we systematically demonstrated the resistance mechanism of EGFR-TKIs, the clinical strategy of each generation of EGFR-TKIs in the synergistic treatment of NSCLC, the treatment-related adverse events of EGFR-TKIs, and the potential role of traditional Chinese medicine in overcoming the resistance and adverse reactions of EGFR-TKIs. Herbs and active compounds have the potential to act synergistically through multiple pathways and multiple mechanisms of overall regulation, combined with targeted therapy, and are expected to be an innovative model for NSCLC treatment

Efficacy and safety of Danggui Niantong Decoction in patients with gout: a systematic review and meta-analysis

Background: This study aims to evaluate the efficacy and safety of Danggui Niantong Decoction (DGNT) systematically on gout treating.Methods: This study was registered in PROSPERO, and the registration number was CRD42021271607. By the end of December, 2022, literature research was conducted among eight electronic databases. Main results of this study were blood uric acid (BUA) and Creactive protein (CRP). Secondary outcomes were erythrocyte sedimentation rate (ESR), serum creatinine (Scr), urinary protein quantified at 24 h (Upro), and interleukin-8 (IL-8). Study screening, data collection, as well as quality assessment were performed by two reviewers independently, and analysis was completed using Stata (SE15.0) and Review Manager (5.4).Results: A total number of 13 studies were included in our meta-analysis (n = 1,094 participants). Results showed DGNT combined with conventional western medicine (CWM) was more effective than WM alone in BUA (weighted mean differences (WMD) = −3.49, 95% confidence interval (CI) [−50.36, −32.59], p = 0.000), CRP (WMD = −41.48, 95% CI [−4.32, −2.66], p = 0.017), ESR (WMD = −6.23, 95% CI [−9.28, −3.17], p = 0.019), Scr (WMD = −18.64, 95% CI [−23.09, −14.19], p = 0.001), Upro (WMD = −0.72, 95% CI [−0.91, −0.53], p = 0.000), and IL-8 (WMD = −4.77, 95% CI [−11.48, 1.94], p = 0.000). None of the adverse effects noted were severe, and no life-threatening event was reported.Conclusion: This study shows that DGNT combined with CWM seems to have an effective clinical therapeutic potential. In addition, it also provides a scientific basis for better clinical application of DGNT in the future.Systematic Review Registration:https://www.crd.york.ac.uk/prospero/display_record.php?ID=CRD42021271607; Identifier: PROSPERO, CRD42021271607

Genome-Wide Association Studies Reveal the Genetic Basis of Ionomic Variation in Rice

Rice (Oryza sativa) is an important dietary source of both essential micronutrients and toxic trace elements for humans. The genetic basis underlying the variations in the mineral composition, the ionome, in rice remains largely unknown. Here, we describe a comprehensive study of the genetic architecture of the variation in the rice ionome performed using genome-wide association studies (GWAS) of the concentrations of 17 mineral elements in rice grain from a diverse panel of 529 accessions, each genotyped at ∼6.4 million single nucleotide polymorphism loci. We identified 72 loci associated with natural ionomic variations, 32 that are common across locations and 40 that are common within a single location. We identified candidate genes for 42 loci and provide evidence for the causal nature of three genes, the sodium transporter gene Os-HKT1;5 for sodium, Os-MOLYBDATE TRANSPORTER1;1 for molybdenum, and Grain number, plant height, and heading date7 for nitrogen. Comparison of GWAS data from rice versus Arabidopsis (Arabidopsis thaliana) also identified well-known as well as new candidates with potential for further characterization. Our study provides crucial insights into the genetic basis of ionomic variations in rice and serves as an important foundation for further studies on the genetic and molecular mechanisms controlling the rice ionome

The effect of tone hyperarticulation in Cantonese infant-directed speech on toddlers’ word recognition in the second year of life

The acoustic properties of infant-directed speech (IDS) have been widely studied, but whether and how young learners’ language development benefits from individual properties remains to be confirmed. This study investigated whether toddlers’ word processing was affected by tone hyperarticulation in the IDS of a tone language. Nineteen- and 23-month-old Cantonese-learning toddlers completed a familiar word recognition task and were tested (a) in the hyperarticulated-tone (HT) condition in which the tonal distances were exaggerated, and (b) in the non-hyperarticulated-tone (NT) condition with smaller tonal distances that resembled those in adult-directed speech. The 19-month-old toddlers performed significantly better in the HT condition than in the NT condition, while the 23-month-olds performed comparably well in both conditions. These findings suggest that tone language learners’ word recognition can be facilitated by tone hyperarticulation in IDS, in the middle of the second year of life; as their language development proceeds, this facilitatory effect appears to largely diminish by the end of the second year of life

Lexical and prosodic pitch modifications in Cantonese infant-directed speech

The functions of acoustic-phonetic modifications in infant-directed speech (IDS) remain a question: do they specifically serve to facilitate language learning via enhanced phonemic contrasts (the hyperarticulation hypothesis) or primarily to improve communication via prosodic exaggeration (the prosodic hypothesis)? The study of lexical tones provides a unique opportunity to shed light on this, as lexical tones are phonemically contrastive, yet their primary cue, pitch, is also a prosodic cue. This study investigated Cantonese IDS and found increased intra-talker variation of lexical tones, which more likely posed a challenge to rather than facilitated phonetic learning. Although tonal space was expanded which could facilitate phonetic learning, its expansion was a function of overall intonational modifications. Similar findings were observed in speech to pets who should not benefit from larger phonemic distinction. We conclude that lexical-tone adjustments in IDS mainly serve to broadly enhance communication rather than specifically increase phonemic contrast for learners

Lexical and prosodic pitch modifications in Cantonese infant-directed speech

The functions of acoustic-phonetic modifications in infant-directed speech (IDS) remain a question: do they specifically serve to facilitate language learning via enhanced phonemic contrasts (the hyperarticulation hypothesis) or primarily to improve communication via prosodic exaggeration (the prosodic hypothesis)? The study of lexical tones provides a unique opportunity to shed light on this, as lexical tones are phonemically contrastive, yet their primary cue, pitch, is also a prosodic cue. This study investigated Cantonese IDS and found increased intra-talker variation of lexical tones, which more likely posed a challenge to rather than facilitated phonetic learning. Although tonal space was expanded which could facilitate phonetic learning, its expansion was a function of overall intonational modifications. Similar findings were observed in speech to pets who should not benefit from larger phonemic distinction. We conclude that lexical-tone adjustments in IDS mainly serve to broadly enhance communication rather than specifically increase phonemic contrast for learners

The effect of tone hyperarticulation in Cantonese infant-directed speech on toddlers’ word recognition in the second year of life

The acoustic properties of infant-directed speech (IDS) have been widely studied, but whether and how young learners’ language development benefits from individual properties remains to be confirmed. This study investigated whether toddlers’ word processing was affected by tone hyperarticulation in the IDS of a tone language. Nineteen- and 23-month-old Cantonese-learning toddlers completed a familiar word recognition task and were tested (a) in the hyperarticulated-tone (HT) condition in which the tonal distances were exaggerated, and (b) in the non-hyperarticulated-tone (NT) condition with smaller tonal distances that resembled those in adult-directed speech. The 19-month-old toddlers performed significantly better in the HT condition than in the NT condition, while the 23-month-olds performed comparably well in both conditions. These findings suggest that tone language learners’ word recognition can be facilitated by tone hyperarticulation in IDS, in the middle of the second year of life; as their language development proceeds, this facilitatory effect appears to largely diminish by the end of the second year of life

Optimization of Grouting Material Mixture Ratio Based on Multi-Objective Optimization and Multi-Attribute Decision-Making

As a solid waste produced by coal combustion, fly ash will cause serious environmental pollution. However, it can be considered as a sustainable and renewable resource to replace partial cement in grouting materials. Fly ash grouting materials re-cement the broken rock mass and improve the mechanical properties of the original structure. It can reinforce the broken surrounding rock of mine roadway. The utilization of fly ash also reduces environmental pollution. Therefore, this paper establishes a new material mixture ratio optimization model to meet the requirement of material property through combining the methods of experimental design and numerical analysis. Based on the Box–Behnken design with 3 factors and 3 levels, a mathematical model is constructed to fit the nonlinear multiple regression functions between material properties and raw materials ratios. The influence of raw materials is analyzed on material properties (the material’s 7-day uniaxial compressive strength, initial setting time, and slurry viscosity). Then, 80 Pareto solutions are obtained through NASG-II algorithm which takes the regression functions as the objective functions for multi-objective optimization of the grouting material ratio. Finally, the best ratio solution of water-cement ratio—0.71, silica fume content—1.73%, and sodium silicate content—2.61% is obtained through the NNRP-TOPSIS method